Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether...

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Vydáno v:Blood Adv
Hlavní autoři: Cines, Douglas B., Yarovoi, Serge V., Zaitsev, Sergei V., Lebedeva, Tatiana, Rauova, Lubica, Poncz, Mortimer, Arepally, Gowthami M., Khandelwal, Sanjay, Stepanova, Victoria, Rux, Ann H., Cuker, Adam, Guo, Cecilia, Ocariza, Linnette Mae, Travers, Richard J., Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Conway, Edward M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744055/
https://ncbi.nlm.nih.gov/pubmed/29296696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000877
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