Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

BACKGROUND: There are no specific treatments for the neurological alterations of cirrhotic patients with minimal hepatic encephalopathy (MHE). Rats with MHE due to portacaval shunt (PCS) show impaired spatial learning. The underlying mechanisms remain unknown. The aims of this work were to assess: (...

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Publicado en:J Neuroinflammation
Main Authors: Hernandez-Rabaza, Vicente, Agusti, Ana, Cabrera-Pastor, Andrea, Fustero, Santos, Delgado, Oscar, Taoro-Gonzalez, Lucas, Montoliu, Carmina, Llansola, Marta, Felipo, Vicente
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625867/
https://ncbi.nlm.nih.gov/pubmed/26511444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0420-7
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