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Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

BACKGROUND: There are no specific treatments for the neurological alterations of cirrhotic patients with minimal hepatic encephalopathy (MHE). Rats with MHE due to portacaval shunt (PCS) show impaired spatial learning. The underlying mechanisms remain unknown. The aims of this work were to assess: (...

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Bibliographische Detailangaben
Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Hernandez-Rabaza, Vicente, Agusti, Ana, Cabrera-Pastor, Andrea, Fustero, Santos, Delgado, Oscar, Taoro-Gonzalez, Lucas, Montoliu, Carmina, Llansola, Marta, Felipo, Vicente
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625867/
https://ncbi.nlm.nih.gov/pubmed/26511444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0420-7
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