Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

BACKGROUND: There are no specific treatments for the neurological alterations of cirrhotic patients with minimal hepatic encephalopathy (MHE). Rats with MHE due to portacaval shunt (PCS) show impaired spatial learning. The underlying mechanisms remain unknown. The aims of this work were to assess: (...

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Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Hernandez-Rabaza, Vicente, Agusti, Ana, Cabrera-Pastor, Andrea, Fustero, Santos, Delgado, Oscar, Taoro-Gonzalez, Lucas, Montoliu, Carmina, Llansola, Marta, Felipo, Vicente
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625867/
https://ncbi.nlm.nih.gov/pubmed/26511444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0420-7
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