OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm

We demonstrate that the pluripotency gene OCT4 has a role in regulating differentiation via Wnt signaling. OCT4 expression levels in human embryonic stem cells increases transiently during the first 24 hr of in vitro differentiation, with OCT4 occupancy increasing at endoderm regulators such as SOX1...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Ying, Lei, Mills, Jason A., French, Deborah L., Gadue, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624996/
https://ncbi.nlm.nih.gov/pubmed/26411902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.08.014
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