Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We s...

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Hlavní autoři: Aksoy, Irene, Jauch, Ralf, Chen, Jiaxuan, Dyla, Mateusz, Divakar, Ushashree, Bogu, Gireesh K, Teo, Roy, Leng Ng, Calista Keow, Herath, Wishva, Lili, Sun, Hutchins, Andrew P, Robson, Paul, Kolatkar, Prasanna R, Stanton, Lawrence W
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616284/
https://ncbi.nlm.nih.gov/pubmed/23474895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.31
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