MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP Dissociation Inhibitor alpha from the GDI/CHM family of RAB GTPase effectors

Photoreceptor outer segments (OS) in the vertebrate retina undergo a process of continual renewal involving shedding of disc membranes that are cleared by phagocytic uptake into the retinal pigment epithelium (RPE). In dystrophic Royal College of Surgeons (RCS) rats, OS phagocytosis is blocked by a...

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Publicado en:Exp Eye Res
Autores principales: Shelby, Shameka J., Feathers, Kecia L., Ganios, Anna M., Jia, Lin, Miller, Jason M., Thompson, Debra A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624558/
https://ncbi.nlm.nih.gov/pubmed/26283020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2015.08.006
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