HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

Mutations in HFE are the most common cause of hereditary hemochromatosis (HH). HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages. However, the mechanism by which HFE regulates hepc...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Blood
Hlavní autoři: Wu, Xing-gang, Wang, Yang, Wu, Qian, Cheng, Wai-Hang, Liu, Wenjing, Zhao, Yueshui, Mayeur, Claire, Schmidt, Paul J., Yu, Paul B., Wang, Fudi, Xia, Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624447/
https://ncbi.nlm.nih.gov/pubmed/24904118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552281
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky