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The General Base in the Thymidylate Synthase Catalyzed Proton Abstraction
The enzyme thymidylate synthase (TSase), an important chemotherapeutic drug target, catalyzes the formation of 2′-deoxythymidine-5′-monophosphate (dTMP), a precursor of one of the DNA building blocks. TSase catalyzes a multi-step mechanism that includes the abstraction of a proton from the C5 of the...
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| Udgivet i: | Phys Chem Chem Phys |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624062/ https://ncbi.nlm.nih.gov/pubmed/25912171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cp01246e |
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