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QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase
The cleavage of covalent C-H bonds is one of the most energetically demanding, yet biologically essential, chemical transformations. Two C-H bond cleavages are involved in the reaction catalyzed by thymidylate synthase (TSase), which provides the sole de novo source of thymidylate (i.e. the DNA base...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3634118/ https://ncbi.nlm.nih.gov/pubmed/23464672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400267q |
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