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The Role of Y94 in Proton and Hydride Transfers Catalyzed by Thymidylate Synthase
Thymidylate synthase (TS) catalyzes the substitution of a carbon-bound proton in a uracil base by a methyl group to yield thymine in the de novo biosynthesis of this DNA base. The enzymatic mechanism involves making and breaking several covalent bonds. Traditionally, a conserved tyrosine (Y94 in E....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556867/ https://ncbi.nlm.nih.gov/pubmed/17999469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701363s |
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