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Hydride Transfer vs. Hydrogen Radical Transfer in Thymidylate Synthase

[Image: see text] The nature of an H-transfer in the thymidylate synthase catalyzed reaction was investigated by comparison of the wild-type enzyme with W80M mutant. The nature of the H-transfer was not affected, as indicated by intrinsic isotope effects and their temperature dependence. These findi...

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Detalhes bibliográficos
Main Authors: Hong, Baoyu, Haddad, Majd, Maley, Frank, Jensen, Jan H., Kohen, Amnon
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253763/
https://ncbi.nlm.nih.gov/pubmed/16637621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja060196o
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