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Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells
Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the structure-activity relationship study of pyoluteorin der...
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出版年: | Cancer Biol Ther |
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主要な著者: | , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
Taylor & Francis
2014
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623387/ https://ncbi.nlm.nih.gov/pubmed/25535900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972799 |
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