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Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Acute myeloid leukemia (AML) is one of the deadliest leukemias for which there is an urgent and unmet need for the development of novel treatment strategies. Multiple drug resistance mechanisms mediate poor drug response and relapse in patients, and a selective Mcl-1 inhibitor has been speculated to...

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Bibliografiske detaljer
Main Authors: Doi, Kenichiro, Liu, Qiang, Gowda, Krishne, Barth, Brian M, Claxton, David, Amin, Shantu, Loughran Jr, Thomas P, Wang, Hong-Gang
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119075/
https://ncbi.nlm.nih.gov/pubmed/24842334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29186
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