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Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Acute myeloid leukemia (AML) is one of the deadliest leukemias for which there is an urgent and unmet need for the development of novel treatment strategies. Multiple drug resistance mechanisms mediate poor drug response and relapse in patients, and a selective Mcl-1 inhibitor has been speculated to...

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Bibliografische gegevens
Hoofdauteurs: Doi, Kenichiro, Liu, Qiang, Gowda, Krishne, Barth, Brian M, Claxton, David, Amin, Shantu, Loughran Jr, Thomas P, Wang, Hong-Gang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119075/
https://ncbi.nlm.nih.gov/pubmed/24842334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29186
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