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Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression

Acute myeloid leukemia (AML) is one of the deadliest leukemias for which there is an urgent and unmet need for the development of novel treatment strategies. Multiple drug resistance mechanisms mediate poor drug response and relapse in patients, and a selective Mcl-1 inhibitor has been speculated to...

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Detalhes bibliográficos
Main Authors: Doi, Kenichiro, Liu, Qiang, Gowda, Krishne, Barth, Brian M, Claxton, David, Amin, Shantu, Loughran Jr, Thomas P, Wang, Hong-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119075/
https://ncbi.nlm.nih.gov/pubmed/24842334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29186
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