Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells

Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the structure-activity relationship study of pyoluteorin der...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Doi, Kenichiro, Gowda, Krishne, Liu, Qiang, Lin, Jyh-Ming, Sung, Shen-Shu, Dower, Christopher, Claxton, David, Loughran, Thomas P, Amin, Shantu, Wang, Hong-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623387/
https://ncbi.nlm.nih.gov/pubmed/25535900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972799
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