Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

The anti-apoptotic BCL-2 family proteins are important targets for cancer chemotherapy. Specific and potent inhibitors of the BCL-2 family, such as ABT-263 (navitoclax) and ABT-199, are only effective against some members of the BCL-2 family but do not target MCL-1, which is commonly amplified in tu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Varadarajan, Shankar, Poornima, Paramasivan, Milani, Mateus, Gowda, Krishne, Amin, Shantu, Wang, Hong-Gang, Cohen, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494965/
https://ncbi.nlm.nih.gov/pubmed/26059440
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