MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

It has been reported that persistent or excessive autophagy promotes cancer cell death during chemotherapy, either by enhancing the induction of apoptosis or mediating autophagic cell death. Here, we show that miR-15a and miR-16 are potent inducers of autophagy. Rictor, a component of mTORC2 complex...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Huang, Nunu, Wu, Jiangbin, Qiu, Wei, Lyu, Qing, He, Jie, Xie, Weidong, Xu, Naihan, Zhang, Yaou
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622988/
https://ncbi.nlm.nih.gov/pubmed/25945419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1040963
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