miR-15 and miR-16 induce apoptosis by targeting BCL2

Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate...

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Hauptverfasser: Cimmino, Amelia, Calin, George Adrian, Fabbri, Muller, Iorio, Marilena V., Ferracin, Manuela, Shimizu, Masayoshi, Wojcik, Sylwia E., Aqeilan, Rami I., Zupo, Simona, Dono, Mariella, Rassenti, Laura, Alder, Hansjuerg, Volinia, Stefano, Liu, Chang-gong, Kipps, Thomas J., Negrini, Massimo, Croce, Carlo M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236577/
https://ncbi.nlm.nih.gov/pubmed/16166262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506654102
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