Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors (≈70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes tar...

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書誌詳細
主要な著者: Calin, George Adrian, Dumitru, Calin Dan, Shimizu, Masayoshi, Bichi, Roberta, Zupo, Simona, Noch, Evan, Aldler, Hansjuerg, Rattan, Sashi, Keating, Michael, Rai, Kanti, Rassenti, Laura, Kipps, Thomas, Negrini, Massimo, Bullrich, Florencia, Croce, Carlo M.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2002
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC137750/
https://ncbi.nlm.nih.gov/pubmed/12434020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242606799
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