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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors (≈70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes tar...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Calin, George Adrian, Dumitru, Calin Dan, Shimizu, Masayoshi, Bichi, Roberta, Zupo, Simona, Noch, Evan, Aldler, Hansjuerg, Rattan, Sashi, Keating, Michael, Rai, Kanti, Rassenti, Laura, Kipps, Thomas, Negrini, Massimo, Bullrich, Florencia, Croce, Carlo M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137750/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12434020/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.242606799
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