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Role of miR-15/16 in CLL

B-cell chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The most common chromosomal abnormalities detectable by cytogenetics include deletion at 13q (55%), 11q (18%), trisomy 12 (12–16%) and 17p (8%). In 2002, we discovered that a microRNA cluster miR-15a/miR-16-1 (miR-15/16) is...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Pekarsky, Y, Croce, C M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262785/
https://ncbi.nlm.nih.gov/pubmed/24971479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.87
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