Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for t...

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Bibliografische gegevens
Gepubliceerd in:Epigenetics
Hoofdauteurs: Carvalho, Alexandra T P, Gouveia, Leonor, Kanna, Charan Raju, Wärmländer, Sebastian K T S, Platts, Jamie A, Kamerlin, Shina Caroline Lynn
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://ncbi.nlm.nih.gov/pubmed/25625845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.988043
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