Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for t...

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Библиографические подробности
Опубликовано в: :Epigenetics
Главные авторы: Carvalho, Alexandra T P, Gouveia, Leonor, Kanna, Charan Raju, Wärmländer, Sebastian K T S, Platts, Jamie A, Kamerlin, Shina Caroline Lynn
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2015
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://ncbi.nlm.nih.gov/pubmed/25625845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.988043
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