Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for t...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Epigenetics
Auteurs principaux: Carvalho, Alexandra T P, Gouveia, Leonor, Kanna, Charan Raju, Wärmländer, Sebastian K T S, Platts, Jamie A, Kamerlin, Shina Caroline Lynn
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://ncbi.nlm.nih.gov/pubmed/25625845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.988043
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires