Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Epigenetics
Main Authors: Carvalho, Alexandra T P, Gouveia, Leonor, Kanna, Charan Raju, Wärmländer, Sebastian K T S, Platts, Jamie A, Kamerlin, Shina Caroline Lynn
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://ncbi.nlm.nih.gov/pubmed/25625845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.988043
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker