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DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG dinucleotides, as in the nuclear genome, but neither the mechanism generating mtDNA methylation nor its functional significance is known. We now report the presence of 5-hydroxymethylcytosine (5hmC) as well as 5mC i...

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Bibliographische Detailangaben
Hauptverfasser: Shock, Lisa S., Thakkar, Prashant V., Peterson, Erica J., Moran, Richard G., Taylor, Shirley M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048134/
https://ncbi.nlm.nih.gov/pubmed/21321201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012311108
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