Functional assessment of antibody oxidation by native mass spectrometry

Oxidation of methionine (Met) residues is one of several chemical degradation pathways for recombinant IgG1 antibodies. Studies using several methodologies have indicated that Met oxidation in the constant IgG1 domains affects in vitro interaction with human neonatal Fc (huFcRn) receptor, which is i...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Haberger, Markus, Heidenreich, Anna-Katharina, Schlothauer, Tilman, Hook, Michaela, Gassner, Jana, Bomans, Katrin, Yegres, Michelle, Zwick, Adrian, Zimmermann, Boris, Wegele, Harald, Bonnington, Lea, Reusch, Dietmar, Bulau, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622615/
https://ncbi.nlm.nih.gov/pubmed/26000623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1052199
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