Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

High-molecular weight aggregates such as antibody dimers and other side products derived from incorrect light or heavy chain association typically represent critical product-related impurities for bispecific antibody formats. In this study, an approach employing ultra-pressure liquid chromatography...

Full description

Saved in:
Bibliographic Details
Published in:MAbs
Main Authors: Haberger, Markus, Leiss, Michael, Heidenreich, Anna-Katharina, Pester, Oxana, Hafenmair, Georg, Hook, Michaela, Bonnington, Lea, Wegele, Harald, Haindl, Markus, Reusch, Dietmar, Bulau, Patrick
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966600/
https://ncbi.nlm.nih.gov/pubmed/26655595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1122150
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items