Identification and Monitoring of Host Cell Proteins by Mass Spectrometry Combined with High Performance Immunochemistry Testing

Biotherapeutics are often produced in non-human host cells like Escherichia coli, yeast, and various mammalian cell lines. A major focus of any therapeutic protein purification process is to reduce host cell proteins to an acceptable low level. In this study, various E. coli host cell proteins were...

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Bibliografiske detaljer
Main Authors: Bomans, Katrin, Lang, Antje, Roedl, Veronika, Adolf, Lisa, Kyriosoglou, Kyrillos, Diepold, Katharina, Eberl, Gabriele, Mølhøj, Michael, Strauss, Ulrike, Schmalz, Christian, Vogel, Rudolf, Reusch, Dietmar, Wegele, Harald, Wiedmann, Michael, Bulau, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842259/
https://ncbi.nlm.nih.gov/pubmed/24312330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081639
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