Functional assessment of antibody oxidation by native mass spectrometry

Oxidation of methionine (Met) residues is one of several chemical degradation pathways for recombinant IgG1 antibodies. Studies using several methodologies have indicated that Met oxidation in the constant IgG1 domains affects in vitro interaction with human neonatal Fc (huFcRn) receptor, which is i...

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Publicat a:MAbs
Autors principals: Haberger, Markus, Heidenreich, Anna-Katharina, Schlothauer, Tilman, Hook, Michaela, Gassner, Jana, Bomans, Katrin, Yegres, Michelle, Zwick, Adrian, Zimmermann, Boris, Wegele, Harald, Bonnington, Lea, Reusch, Dietmar, Bulau, Patrick
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622615/
https://ncbi.nlm.nih.gov/pubmed/26000623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1052199
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