Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress conditions to investigate the influence of protein degradation on structure-function. Extensive purificatio...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Schmid, Ingrid, Bonnington, Lea, Gerl, Monika, Bomans, Katrin, Thaller, Anna Louisa, Wagner, Katharina, Schlothauer, Tilman, Falkenstein, Roberto, Zimmermann, Boris, Kopitz, Jürgen, Hasmann, Max, Bauss, Frieder, Haberger, Markus, Reusch, Dietmar, Bulau, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123738/
https://ncbi.nlm.nih.gov/pubmed/30271914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0032-8
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