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Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?

Another piece of the thalidomide puzzle is unraveled through structural studies of thalidomide and its derivatives bound to its protein target cereblon. Two recent studies published in Nature (Fischer et al.) and Nature Structural & Molecular Biology (Chamberlain et al.) have shed light on the d...

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Detalles Bibliográficos
Publicado en:Cancer Biol Ther
Autores principales: Ley, Ariel M, Chau, Cindy H, Figg, William D
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622570/
https://ncbi.nlm.nih.gov/pubmed/25692618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972828
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