Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

Proteins of the death domain (DD) superfamily mediate assembly of oligomeric signaling complexes for the activation of caspases and kinases via unknown mechanisms. Here we report the crystal structure of the PIDD DD and RAIDD DD complex, which forms the core of the caspase-2 activating complex PIDDo...

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Bibliografiska uppgifter
Huvudupphovsmän: Park, Hyun Ho, Logette, Emmanuelle, Raunser, Stefan, Cuenin, Solange, Walz, Thomas, Tschopp, Jurg, Wu, Hao
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908332/
https://ncbi.nlm.nih.gov/pubmed/17289572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.01.019
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