Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

Proteins of the death domain (DD) superfamily mediate assembly of oligomeric signaling complexes for the activation of caspases and kinases via unknown mechanisms. Here we report the crystal structure of the PIDD DD and RAIDD DD complex, which forms the core of the caspase-2 activating complex PIDDo...

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Autores principales: Park, Hyun Ho, Logette, Emmanuelle, Raunser, Stefan, Cuenin, Solange, Walz, Thomas, Tschopp, Jurg, Wu, Hao
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908332/
https://ncbi.nlm.nih.gov/pubmed/17289572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.01.019
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