Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients

Histone deacetylases (HDAC) play a crucial role in transcriptional regulation and are often deregulated in many cancers. However, global HDAC enzymatic activity has never been investigated in Chronic Lymphocytic Leukemia (CLL). We measured HDAC activity in protein extracts from CD19+ B-cells purifie...

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發表在:Epigenetics
Main Authors: Van Damme, Michaël, Crompot, Emerence, Meuleman, Nathalie, Mineur, Philippe, Dessars, Barbara, El Housni, Hakim, Bron, Dominique, Lagneaux, Laurence, Stamatopoulos, Basile
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2014
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622440/
https://ncbi.nlm.nih.gov/pubmed/25437053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.969628
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