HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance

Histone deacetylases (HDACs) play a crucial role in chromatin structure and, consequently, gene expression. Their deregulation has been reported in various cancers. We performed a complete and comprehensive study of the expression of 18 HDACs (including Sirtuin; SIRT) by real-time PCR in a cohort of...

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Detalhes bibliográficos
Main Authors: Van Damme, Michaël, Crompot, Emerence, Meuleman, Nathalie, Mineur, Philippe, Bron, Dominique, Lagneaux, Laurence, Stamatopoulos, Basile
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528695/
https://ncbi.nlm.nih.gov/pubmed/23108383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.22674
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