Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients

Histone deacetylases (HDAC) play a crucial role in transcriptional regulation and are often deregulated in many cancers. However, global HDAC enzymatic activity has never been investigated in Chronic Lymphocytic Leukemia (CLL). We measured HDAC activity in protein extracts from CD19+ B-cells purifie...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Van Damme, Michaël, Crompot, Emerence, Meuleman, Nathalie, Mineur, Philippe, Dessars, Barbara, El Housni, Hakim, Bron, Dominique, Lagneaux, Laurence, Stamatopoulos, Basile
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622440/
https://ncbi.nlm.nih.gov/pubmed/25437053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.969628
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