The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells

BACKGROUND: Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and s...

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Detalhes bibliográficos
Main Authors: Stamatopoulos, Basile, Meuleman, Nathalie, De Bruyn, Cécile, Delforge, Alain, Bron, Dominique, Lagneaux, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895038/
https://ncbi.nlm.nih.gov/pubmed/20145270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.013847
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