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Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils
Light chain (AL) amyloidosis is an incurable human disease, where the amyloid precursor is a misfolding-prone immunoglobulin light-chain. Here, we identify the role of somatic mutations in the structure, stability and in vitro fibril formation for an amyloidogenic AL-12 protein by restoring four non...
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| Published in: | Protein Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley & Sons, Ltd
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622216/ https://ncbi.nlm.nih.gov/pubmed/26300552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2790 |
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