Thermodynamic and Fibril Formation Studies of Full Length Immunoglobulin Light Chain AL-09 and its germline protein using Scan Rate Dependent Thermal Unfolding

Light chain (AL) amyloidosis is a fatal disease where monoclonal immunoglobulin light chains deposit as insoluble amyloid fibrils. For many years it has been considered that AL amyloid deposits are formed primarily by the variable domain, while its constant domain has been considered not to be amylo...

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Bibliographic Details
Published in:Biophys Chem
Main Authors: Blancas-Mejía, Luis M., Horn, Timothy J., Marin-Argany, Marta, Auton, Matthew, Tischer, Alexander, Ramirez-Alvarado, Marina
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662889/
https://ncbi.nlm.nih.gov/pubmed/26263488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2015.07.005
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