Processing of complex N-glycans in IgG Fc-region is affected by core fucosylation

We investigated N-glycan processing of immunoglobulin G1 using the monoclonal antibody cetuximab (CxMab), which has a glycosite in the Fab domain in addition to the conserved Fc glycosylation, as a reporter. Three GlcNAc (Gn) terminating bi-antennary glycoforms of CxMab differing in core fucosylatio...

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Veröffentlicht in:MAbs
Hauptverfasser: Castilho, Alexandra, Gruber, Clemens, Thader, Andreas, Oostenbrink, Chris, Pechlaner, Maria, Steinkellner, Herta, Altmann, Friedrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622071/
https://ncbi.nlm.nih.gov/pubmed/26067753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1053683
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