δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine

BACKGROUND AND PURPOSE: The K(v)7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABA(A) receptors and K(v)7 channels in neurons of pain pathways, but not in hippocampus. EXPERIM...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Klinger, Felicia, Bajric, Mirnes, Salzer, Isabella, Dorostkar, Mario M., Khan, Deeba, Pollak, Daniela D., Kubista, Helmut, Boehm, Stefan, Koenig, Xaver
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621994/
https://ncbi.nlm.nih.gov/pubmed/26211808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13262
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