δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine

BACKGROUND AND PURPOSE: The K(v)7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABA(A) receptors and K(v)7 channels in neurons of pain pathways, but not in hippocampus. EXPERIM...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Klinger, Felicia, Bajric, Mirnes, Salzer, Isabella, Dorostkar, Mario M., Khan, Deeba, Pollak, Daniela D., Kubista, Helmut, Boehm, Stefan, Koenig, Xaver
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621994/
https://ncbi.nlm.nih.gov/pubmed/26211808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13262
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