δ Subunit‐containing GABA(A) receptors are preferred targets for the centrally acting analgesic flupirtine

BACKGROUND AND PURPOSE: The K(v)7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABA(A) receptors and K(v)7 channels in neurons of pain pathways, but not in hippocampus. EXPERIM...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Klinger, Felicia, Bajric, Mirnes, Salzer, Isabella, Dorostkar, Mario M., Khan, Deeba, Pollak, Daniela D., Kubista, Helmut, Boehm, Stefan, Koenig, Xaver
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621994/
https://ncbi.nlm.nih.gov/pubmed/26211808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13262
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