Concomitant facilitation of GABA(A) receptors and K(V)7 channels by the non-opioid analgesic flupirtine

BACKGROUND AND PURPOSE: Flupirtine is a non-opioid analgesic that has been in clinical use for more than 20 years. It is characterized as a selective neuronal potassium channel opener (SNEPCO). Nevertheless, its mechanisms of action remain controversial and are the purpose of this study. EXPERIMENTA...

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Detalhes bibliográficos
Main Authors: Klinger, Felicia, Geier, Petra, Dorostkar, Mario M, Chandaka, Giri K, Yousuf, Arsalan, Salzer, Isabella, Kubista, Helmut, Boehm, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419907/
https://ncbi.nlm.nih.gov/pubmed/22188423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01821.x
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