Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) represent highly pathogenic human CoVs that share a property to inhibit host gene expression at the posttranscriptional level. Similar to the nonstructural protein 1 (nsp1)...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Lokugamage, Kumari G., Narayanan, Krishna, Nakagawa, Keisuke, Terasaki, Kaori, Ramirez, Sydney I., Tseng, Chien-Te K., Makino, Shinji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Virus-Cell Interactions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621111/
https://ncbi.nlm.nih.gov/pubmed/26311885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01352-15
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