SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous study demonstrated that nsp1 induces RNA modificat...

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Detalhes bibliográficos
Main Authors: Huang, Cheng, Lokugamage, Kumari G., Rozovics, Janet M., Narayanan, Krishna, Semler, Bert L., Makino, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234236/
https://ncbi.nlm.nih.gov/pubmed/22174690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002433
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