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Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) represent highly pathogenic human CoVs that share a property to inhibit host gene expression at the posttranscriptional level. Similar to the nonstructural protein 1 (nsp1)...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Lokugamage, Kumari G., Narayanan, Krishna, Nakagawa, Keisuke, Terasaki, Kaori, Ramirez, Sydney I., Tseng, Chien-Te K., Makino, Shinji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621111/
https://ncbi.nlm.nih.gov/pubmed/26311885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01352-15
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