Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) represent highly pathogenic human CoVs that share a property to inhibit host gene expression at the posttranscriptional level. Similar to the nonstructural protein 1 (nsp1)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lokugamage, Kumari G., Narayanan, Krishna, Nakagawa, Keisuke, Terasaki, Kaori, Ramirez, Sydney I., Tseng, Chien-Te K., Makino, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621111/
https://ncbi.nlm.nih.gov/pubmed/26311885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01352-15
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