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Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoEM

Secretory and membrane proteins from mammalian cells undergo post-translational modifications, including N-linked glycosylation, which can result in a large number of possible glycoforms. This sample heterogeneity can be problematic for structural studies, particularly X-ray crystallography. Thus, c...

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Foilsithe in:Structure
Main Authors: Lee, Jeong Hyun, de Val, Natalia, Lyumkis, Dmitry, Ward, Andrew B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618500/
https://ncbi.nlm.nih.gov/pubmed/26388028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.07.020
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